Issue
Selecting the Save to SharePoint or Open from SharePoint option in Adobe Reader or Adobe Acrobat displays the following message.

Resolution
In Adobe Reader, choose Edit --> Preferences --> Security (Enhanced) untick Enable Protected Mode at startup

Alternatively it can be set via the following registry key:
[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\###\Privileged]
"bProtectedMode"=dword:00000000
Alternatively, refer to this Adobe technote
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SharePoint, Office, Windows and Adobe version support
Eliminating Prompts when opening PDFs from SharePoint using MacroView
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