Disable protected mode message in Adobe Reader DC

Issue

Selecting the Save to SharePoint or Open from SharePoint option in Adobe Reader or Adobe Acrobat displays the following message.

Resolution

In Adobe Reader, choose Edit --> Preferences --> Security (Enhanced) untick Enable Protected Mode at startup

Alternatively it can be set via the following registry key:

[HKEY_CURRENT_USER\Software\Adobe\Acrobat Reader\###\Privileged]

"bProtectedMode"=dword:00000000

Alternatively, refer to this Adobe technote

More Adobe articles:

SharePoint, Office, Windows and Adobe version support